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Comment
. 2010 Oct 19;18(4):301-2.
doi: 10.1016/j.ccr.2010.10.001.

BRAF inhibitor unveils its potential against advanced melanoma

Adina Vultur  1 , Jessie Villanueva, Meenhard Herlyn
Affiliations
Free article
Comment

BRAF inhibitor unveils its potential against advanced melanoma

Adina Vultur et al. Cancer Cell. .
Free article

Abstract

Unresponsiveness to therapy is a hallmark feature of advanced metastatic melanoma. However, the discovery of BRAF-activating mutations in approximately 50% of human melanomas has provided an attractive therapeutic target. Here, we discuss two recent publications focusing on the mutant BRAF kinase inhibitor PLX4032 that validate oncogene-targeted melanoma therapy.

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