MicroRNAs and LPS: developing a relationship in the neonatal gut
- PMID: 20951963
- DOI: 10.1016/j.chom.2010.10.001
MicroRNAs and LPS: developing a relationship in the neonatal gut
Abstract
Upon birth, the intestine converts from a sterile environment to a home for commensal microorganisms. How immune homeostasis is maintained during this transition is not well understood. Here, Chassin et al. (2010) demonstrate that microRNA-146a regulates the responsiveness of intestinal epithelial cells during microbial colonization of the neonatal intestine.
Copyright © 2010 Elsevier Inc. All rights reserved.
Comment on
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miR-146a mediates protective innate immune tolerance in the neonate intestine.Cell Host Microbe. 2010 Oct 21;8(4):358-68. doi: 10.1016/j.chom.2010.09.005. Cell Host Microbe. 2010. PMID: 20951969
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