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Editorial
. 2010 Dec;299(6):L721-3.
doi: 10.1152/ajplung.00365.2010. Epub 2010 Oct 15.

Keratinocyte growth factor improves alveolar barrier function: keeping claudins in line

Michael Koval
Editorial

Keratinocyte growth factor improves alveolar barrier function: keeping claudins in line

Michael Koval. Am J Physiol Lung Cell Mol Physiol. 2010 Dec.
No abstract available

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Figures

Fig. 1.
Fig. 1.
Cytoskeletal rearrangement induced by keratinocyte growth factor (KGF) treatment of alveolar epithelial cells. A and B: diagram indicating the orientation of actin filaments in cells cultured in control medium forming stress fibers (A) or in the presence of KGF, which are predominantly peri-junctional, cortical actin (B). C and D: attachment of transmembrane tight junction proteins (claudins, occludin) to the actin cytoskeleton via the scaffold protein zonula occludens-1 (ZO-1). Increased peri-junctional bundles of actin fibers provide more ZO-1 attachment sites, which stabilize tight junction strands, thus promoting their barrier function. Not depicted in this diagram are other classes of scaffold and transmembrane proteins, which also crosslink tight junctions to the cytoskeleton.
See this image and copyright information in PMC

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References

    1. Abraham V, Chou ML, DeBolt KM, Koval M. Phenotypic control of gap junctional communication by cultured alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 276: L825–L834, 1999 - PubMed
    1. Aguilar S, Scotton CJ, McNulty K, Nye E, Stamp G, Laurent G, Bonnet D, Janes SM. Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS One 4: e8013, 2009 - PMC - PubMed
    1. Anderson JM, Van Itallie CM. Physiology and function of the tight junction. Cold Spring Harb Perspect Biol 1: a002584, 2009 - PMC - PubMed
    1. Angelow S, Ahlstrom R, Yu AS. Biology of claudins. Am J Physiol Renal Physiol 295: F867–F876, 2008 - PMC - PubMed
    1. Boardman KC, Aryal AM, Miller WM, Waters CM. Actin re-distribution in response to hydrogen peroxide in airway epithelial cells. J Cell Physiol 199: 57–66, 2004 - PubMed

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