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. 2011:2011:912935.
doi: 10.1155/2011/912935. Epub 2010 Sep 8.

Analgesic and Anti-Inflammatory Properties of Extracts from the Bulbils of Dioscorea bulbifera L. var sativa (Dioscoreaceae) in Mice and Rats

M Mbiantcha  1 , A Kamanyi, R B Teponno, A L Tapondjou, P Watcho, T B Nguelefack
Affiliations

Analgesic and Anti-Inflammatory Properties of Extracts from the Bulbils of Dioscorea bulbifera L. var sativa (Dioscoreaceae) in Mice and Rats

M Mbiantcha et al. Evid Based Complement Alternat Med. 2011.

Abstract

The aqueous and methanol extracts from the dry bulbils of Dioscorea bulbifera L. var sativa (Dioscoreaceae)-evaluated orally at the doses of 300 and 600 mg/kg against pain induced by acetic acid, formalin, pressure and against inflammation induced by carrageenan, histamine, serotonin and formalin in mice and rats, showed a dose dependant inhibition of pain and inflammation with a maximum effect of 56.38%, 73.06% and 42.79% produced by the aqueous extract, respectively on pain induced by acetic acid, formalin and pressure while the methanol extract at the same dose respectively inhibited these models of pain by 62.70%, 84.54% and 47.70%. The oral administration of aqueous and methanol extracts caused significant anti-inflammatory activity on paw oedema induced by histamine, serotonin and formalin. The present results show that the bulbils of Dioscorea bulbifera var sativa possess potent analgesic and anti-inflammatory activities. These activities may results from the inhibition of inflammatory mediators such as histamine, serotonin and prostaglandins. Thus, the analgesic activity of the bulbils of Dioscorea bulbifera may be at least partially linked to its anti-inflammatory activity.

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Figures

Figure 1
Figure 1
Effects of aqueous and methanol extracts of the bulbils of Dioscorea bulbifera L. var sativa on acetic acid-induced pain in mice. Each bar represents the mean ± SEM of 6 animals; c P < .001 statistically significant compared to their respective control.
Figure 2
Figure 2
Effects of aqueous (EA) (a) and methanol (EM) (b) extracts of the bulbils of Dioscorea bulbifera L. var sativa on formalin-induced pain in mice. Each bar represents the mean ± SEM of 6 animals; c P < .001 statistically significant compared to their respective control.
Figure 3
Figure 3
Antinociceptive effects of aqueous (EA) (a) and methanol (EM) (b) extracts of the bulbils of Dioscorea bulbifera L. var sativa in pressure-caused pain. Each point represents the mean ± SEM of 6 animals; a P < .05; b P < .01, statistically significant compared to their respective control.
Figure 4
Figure 4
Anti-inflammatory effects of aqueous (EA) (a) and methanol (EM) (b) extracts of the bulbils of Dioscorea bulbifera L. var sativa on rat hind paw oedema induced by carrageenan. Each point represents the mean ± SEM of 6 animals; a P < .05; b P < .01, c P < .001 statistically significant compared to their respective control.
Figure 5
Figure 5
Effects of aqueous and methanol extracts of the bulbils of Dioscorea bulbifera L. var sativa on paw oedema induced by histamine (a) and serotonin (b). Each bar represents the mean ± SEM of 6 animals; c P < .001 statistically significant compared to their respective control.
Figure 6
Figure 6
Effects of aqueous (EA) (a) and methanol (EM) (b) extracts of the bulbils of Dioscorea bulbifera L. var sativa on acute inflammation of paw oedema induced by formalin. Each point represents the mean ± SEM of 6 animals; b P < .01; c P < .001 statistically significant compared to their respective control.
Figure 7
Figure 7
Effects of aqueous (EA) (a) and methanol (EM) (b) extracts of the bulbils of Dioscorea bulbifera L. var sativa on chronic inflammation of paw oedema induced by formalin. Each point represents the mean ± SEM of 6 animals; a P < .05; b P < .01, c P < .001 statistically significant compared to negative control.
Figure 8
Figure 8
Probable mechanism of the analgesic and anti-inflammatory activities of Dioscorea bulbifera extracts.
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