Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990;39(6):603-5.
doi: 10.1007/BF00316106.

Stereoselectivity of cholinesterase inhibition by galanthamine and tolerance in humans

T Thomsen  1 , U Bickel, J P Fischer, H Kewitz
Affiliations

Stereoselectivity of cholinesterase inhibition by galanthamine and tolerance in humans

T Thomsen et al. Eur J Clin Pharmacol. 1990.

Abstract

The effect of galanthamine (GAL) and its 2 major metabolites on human cholinesterases has been explored. Epigalanthamine, a diastereomer of GAL, was 130-times less potent in vitro in its effect on acetylcholinesterase (AChE) in erythrocytes than the parent compound, and it did not differ significantly from the ketone galanthaminone. In vivo, the maximal 36-55% inhibition of AChE was approached 30 min after oral administration of 10 mg GAL. The duration of the catalytic inhibition corresponded to an elimination half-life of approximately 5-7 h. GAL was well tolerated in 8/8 healthy volunteers, and 3/4 Alzheimer patients tolerated the drug up to a daily dose of 40 mg.

PubMed Disclaimer

References

    1. Ann N Y Acad Sci. 1966 Jan 26;135(1):287-301 - PubMed
    1. Pharmacology. 1989;39(1):50-8 - PubMed
    1. Anaesthesist. 1976 Sep;25(9):444-8 - PubMed
    1. Life Sci. 1990;46(21):1553-8 - PubMed
    1. J Chromatogr. 1987 Oct 30;421(2):396-400 - PubMed

LinkOut - more resources