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Review
. 2010 Dec;19(10):1419-27.
doi: 10.1007/s11136-010-9757-7. Epub 2010 Oct 16.

I'm so tired: biological and genetic mechanisms of cancer-related fatigue

Andrea Barsevick  1 , Marlene Frost, Aeilko Zwinderman, Per Hall, Michele Halyard; GENEQOL Consortium
Collaborators, Affiliations
Review

I'm so tired: biological and genetic mechanisms of cancer-related fatigue

Andrea Barsevick et al. Qual Life Res. 2010 Dec.

Abstract

Objective: The goal of this paper is to discuss cancer-related fatigue (CRF) and address issues related to the investigation into potential biological and genetic causal mechanisms. The objectives are to: (1) describe CRF as a component of quality of life (QOL); (2) address measurement issues that have slowed progress toward an understanding of mechanisms underlying this symptom; (3) review biological pathways and genetic approaches that have promise for the exploration of causal mechanisms of CRF; and (4) offer directions for future research.

Methods: Review, synthesis, and interpretation of the literature.

Results: Until recently, CRF and QOL have been understood primarily as subjective patient-reported experiences. With increased understanding of human genetics, theories and research are being expanded to incorporate biological and genetic understandings of these subjective experiences. Proposed biological and genetic mechanisms of CRF that have been examined include cytokine dysregulation, hypothalamic-pituitary-adrenal (HPA) axis dysfunction, five hydroxy tryptophan (5-HT) neurotransmitter dysregulation, circadian rhythm disruption, alterations in adenosine triphosphate (ATP) and muscle metabolism, and vagal afferent activation. Approaches to the study of genetic mechanisms have also been addressed including candidate genes, genome-wide scanning, and gene expression. Based on the review and synthesis of the literature, directions for future research are proposed.

Conclusions: Understanding the biological and genetic basis of CRF has the potential to contribute to a more complete understanding of the genetic determinants of QOL.

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References

    1. Higginson IJ, Armes J, Krishnasamy M. Introduction, in fatigue in cancer. In: Armes J, Krishnasamy M, Higginson IJ, editors. Fatigue in Cancer. Oxford University Press; Oxford: 2004. pp. xvii–xxi.
    1. Cella D, Davis K, Breitbart W, Curt G. Cancer-related fatigue: prevalence of proposed diagnostic criteria in a United States sample of cancer survivors. Journal of Clinical Oncology. 2001;19(14):3385–91. - PubMed
    1. Servaes P, Verhagen C, Bleijenberg G. Fatigue in cancer patients during and after treatment: prevalence, correlates and interventions. European Journal of Cancer. 2002;38(1):27–43. - PubMed
    1. Smets EM, Garssen B, Cull A, de Haes JC. Application of the multidimensional fatigue inventory (MFI-20) in cancer patients receiving radiotherapy. British Journal of Cancer. 1996;73(2):241–5. - PMC - PubMed
    1. Curt GA, Breitbart W, Cella D, Groopman JE, Horning SJ, Itri LM, Johnson DH, Miaskowski C, et al. Impact of cancer-related fatigue on the lives of patients: New findings from the Fatigue Coalition. The Oncologist. 2000;5(5):353–60. - PubMed