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Multicenter Study
. 2010;12(5):R193.
doi: 10.1186/ar3164. Epub 2010 Oct 18.

Lifestyle factors and lumbar disc disease: results of a German multi-center case-control study (EPILIFT)

Barbara Schumann  1 , Ulrich Bolm-Audorff, Annekatrin Bergmann, Rolf Ellegast, Gine Elsner, Joachim Grifka, Johannes Haerting, Matthias Jäger, Martina Michaelis, Andreas Seidler
Affiliations
Multicenter Study

Lifestyle factors and lumbar disc disease: results of a German multi-center case-control study (EPILIFT)

Barbara Schumann et al. Arthritis Res Ther. 2010.

Abstract

Introduction: In the large-scale case-control study EPILIFT, we investigated the dose-response relationship between lifestyle factors (weight, smoking amount, cumulative duration of different sports activities) and lumbar disc disease.

Methods: In four German study regions (Frankfurt am Main, Freiburg, Halle/Saale, Regensburg), 564 male and female patients with lumbar disc herniation and 351 patients with lumbar disc narrowing (chondrosis) aged 25 to 70 years were prospectively recruited. From the regional population registers, 901 population control subjects were randomly selected. In a structured personal interview, we enquired as to body weight at different ages, body height, cumulative smoking amount and cumulative duration of different sports activities. Confounders were selected according to biological plausibility and to the change-in-estimate criterion. Adjusted, gender-stratified odds ratios with 95% confidence intervals were calculated using unconditional logistic regression analysis.

Results: The results of this case-control study reveal a positive association between weight and lumbar disc herniation as well as lumbar disc narrowing among men and women. A medium amount of pack-years was associated with lumbar disc herniation and narrowing in men and women. A non-significantly lowered risk of lumbar disc disease was found in men with high levels of cumulative body building and strength training.

Conclusions: According to our multi-center case-control study, body weight might be related to lumbar disc herniation as well as to lumbar disc narrowing. Further research should clarify the potential protective role of body building or strength training on lumbar disc disease.

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References

    1. Kauppila LI. Atherosclerosis and disc degeneration/low-back pain - a systematic review. Eur J Vasc Endovasc Surg. 2009;37:661–670. doi: 10.1016/j.ejvs.2009.02.006. - DOI - PubMed
    1. Seidler A, Bergmann A, Jäger M, Ellegast R, Ditchen D, Elsner G, Grifka J, Haerting J, Hofmann F, Linhardt O, Luttmann A, Michaelis M, Petereit-Haack G, Schumann B, Bolm-Audorff U. Cumulative occupational lumbar load and lumbar disc disease - results of a German multi-center case-control study (EPILIFT) BMC Musculoskeletal Disorders. 2009;10:48. doi: 10.1186/1471-2474-10-48. - DOI - PMC - PubMed
    1. Linhardt O, Bolm-Audorff U, Bergmann A, Ditchen D, Ellegast R, Elsner G, Haerting J, Hofmann F, Jäger M, Luttmann A, Michaelis M, Petereit-Haack G, Seidler A, Grifka J. Studiendesign der Deutschen Wirbelsäulenstudie [Study design of the German Spine Study] Zbl Arbeitsmed. 2007;57:243–250.
    1. Bolm-Audorff U, Brandenburg S, Brüning T, Dupuis H, Ellegast R, Elsner G, Franz K, Grasshoff H, Grosser V, Hanisch L, Hartmann B, Hartung E, Hering KG, Heuchert G, Jäger M, Krämer J, Kranig A, Ludolph E, Luttmann A, Nienhaus A, Pieper W, Pöhl KD, Remé T, Riede D, Rompe G, Schäfer K, Schilling S, Schmitt E, Schröter F, Seidler A, Spallek M, Weber M. Medizinische Beurteilungskriterien zu bandscheibenbedingten Berufskrankheiten der Lendenwirbelsäule (I) Konsensempfehlungen zur Zusammenhangsbegutachtung der auf Anregung des HVBG eingerichteten interdisziplinären Arbeitsgruppe [Medical evaluation criteria for occupational diseases of the lumbar spine related to the intervertebral disc. Consensus recommendations for assessing the interrelationship as proposed by the interdisciplinary working group established by the HVBG] Trauma und Berufskrankheit. 2005;7:211–252. doi: 10.1007/s10039-005-1027-5. - DOI
    1. Richter P, Hemmann E, Merboth H, Fritz S, Hansgen C, Rudolf M. Das Erleben von Arbeitsintensität und Tätigkeitsspielraum - Entwicklung und Validierung eines Fragebogens zur orientierenden Analyse (FIT) [Perceived work intensity and activity latitude: development and validation of a questionnaire] Z Arbeits-Organisationspsychol. 2000;44:129–139. doi: 10.1026//0932-4089.44.3.129. - DOI

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