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. 2010 Oct 21;68(2):182-6.
doi: 10.1016/j.neuron.2010.10.003.

The psychiatric GWAS consortium: big science comes to psychiatry

Patrick F Sullivan  1
Affiliations

The psychiatric GWAS consortium: big science comes to psychiatry

Patrick F Sullivan. Neuron. .

Abstract

The Psychiatric GWAS Consortium was founded with the aim of conducting statistically rigorous and comprehensive GWAS meta-analyses for five major psychiatric disorders: ADHD, autism, bipolar disorder, major depressive disorder, and schizophrenia. In the era of GWAS and high-throughput genomics, a major trend has been the emergence of collaborative, consortia approaches. Taking advantage of the scale that collaborative consortia approaches can bring to a problem, the PGC has been a major driver in psychiatric genetics and provides a model for how similar approaches may be applied to other disease communities.

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Figures

Figure 1
Figure 1
Depicted are 587 associations for 76 human diseases. Each association is plotted as its genotypic relative risk by the risk allele frequency in controls (both on log10 scale). The insert shows the 10 diseases with the greatest numbers of associations. Red crosses show findings for neurological disorders (Alzheimer disease, amyotrophic lateral sclerosis, essential tremor, multiple sclerosis, narcolepsy, and Parkinson disease). Psychiatric disorders are indicated with plus marks including autism (blue), mood disorders (green), and schizophrenia (fuchsia). All other biomedical disorders are shown by grey dots.
See this image and copyright information in PMC

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