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Review
. 2010 Oct 21;68(2):201-6.
doi: 10.1016/j.neuron.2010.10.014.

Genetic analysis of pathways to Parkinson disease

John Hardy  1
Affiliations
Review

Genetic analysis of pathways to Parkinson disease

John Hardy. Neuron. .

Abstract

In this review I outline the arguments as to whether we should consider Parkinson disease one or more than one entity and discuss genetic findings from Mendelian and whole-genome association analysis in that context. I discuss what the demonstration of disease spread implies for our analysis of the genetic and epidemiologic risk factors for disease and outline the surprising fact that we now have genetically identified on the order of half our risk for developing the disease.

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References

    1. Bonifati V., Rohé C.F., Breedveld G.J., Fabrizio E., De Mari M., Tassorelli C., Tavella A., Marconi R., Nicholl D.J., Chien H.F., Italian Parkinson Genetics Network Early-onset parkinsonism associated with PINK1 mutations: Frequency, genotypes, and phenotypes. Neurology. 2005;65:87–95. - PubMed
    1. Braak H., Braak E. Evolution of neuronal changes in the course of Alzheimer's disease. J. Neural Transm. Suppl. 1998;53:127–140. - PubMed
    1. Braak H., Del Tredici K., Rüb U., de Vos R.A., Jansen Steur E.N., Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging. 2003;24:197–211. - PubMed
    1. Brundin P., Li J.Y., Holton J.L., Lindvall O., Revesz T. Research in motion: The enigma of Parkinson's disease pathology spread. Nat. Rev. Neurosci. 2008;9:741–745. - PubMed
    1. Burré J., Sharma M., Tsetsenis T., Buchman V., Etherton M., Südhof T.C. {alpha}- synuclein promotes SNARE-complex assembly in vivo and in vitro. Science. 2010 in press. Published online August 26, 2010. - PMC - PubMed

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