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. 2010 Nov;110(5):593-6.
doi: 10.1016/j.tripleo.2010.05.067.

Management of bisphosphonate-associated osteonecrosis: pentoxifylline and tocopherol in addition to antimicrobial therapy. An initial case series

Matthew S Epstein  1 , Fredrick W Wicknick, Joel B Epstein, James R Berenson, Meir Gorsky
Affiliations

Management of bisphosphonate-associated osteonecrosis: pentoxifylline and tocopherol in addition to antimicrobial therapy. An initial case series

Matthew S Epstein et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Nov.

Abstract

Background: Studies of the use of pentoxifylline and α-tocopherol in osteoradionecrosis of the jaw have suggested their efficacy in this condition. We report an initial case series of pentoxifylline and α-tocopherol for patients with bisphosphonate-associated osteonecrosis (BON).

Methods: Six cases referred for management of BON were provided pentoxifylline and α-tocopherol in addition to antimicrobial therapy, and followed for a mean of 10 months.

Results: A 74% decrease in area of bony exposure and symptom control was achieved in these cases.

Discussion: Pentoxifylline with α-tocopherol may represent a strategy for management of BON. Controlled trials in cases of BON appear warranted.

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