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. 2010 Oct 5:4:1137-43.
doi: 10.2147/OPTH.S13884.

Two-year treatment patterns and costs in glaucoma patients initiating treatment with prostaglandin analogs

Jordana K Schmier  1 , Edmund C Lau, David W Covert
Affiliations

Two-year treatment patterns and costs in glaucoma patients initiating treatment with prostaglandin analogs

Jordana K Schmier et al. Clin Ophthalmol. .

Abstract

Objective: To determine treatment patterns and costs over a two-year period among new initiators of topical prostaglandin analogs in a managed care population by retrospective cohort analysis of an insurance claims database.

Methods: Patients who initiated therapy with a prostaglandin analog between September 2006 and March 2007 were identified. The use of monotherapy and adjunctive therapies were compared by index prostaglandin. Days to initiation of adjunctive therapy and rates of glaucoma surgical procedures were also calculated. Medical costs (antiglaucoma medications and ophthalmic visits) over the two-year period were estimated.

Results: The analysis identified 5018 patients with at least one prostaglandin analog prescription (bimatoprost, n = 747; latanoprost, n = 1651; benzalkonium chloride (BAK)-free travoprost, n = 203). The majority (51%-54%) had repeat prescriptions. Among those with repeat prescriptions, 52% were female (not significant) and mean age was 64 years (P < 0.01). Rates of adjunctive therapy use varied across groups (bimatoprost 51%, latanoprost 37%, and BAK- free travoprost 35%, P < 0.0001). Median and mean days to initiation of adjunctive therapy were 83 and 140 for bimatoprost, 101 and 181 for latanoprost, and 113 and 221 for BAK- free travoprost. Two-year medical costs were $3147, $2843, and $2557 for patients initiating treatment with bimatoprost, latanoprost, and BAK-free travoprost, respectively. Use of glaucoma surgical procedures across the treatment groups was similar over the two-year period.

Conclusions: Over a two-year period, the rate and time to initiation of adjunctive therapy use, as well as medical costs, varied between index prostaglandins. However, the rate of glaucoma surgical interventions did not vary significantly across index medications.

Keywords: combination; costs and cost analysis; drug therapy; glaucoma; prostaglandin analogs.

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References

    1. Konstas AG, Maskaleris G, Gratsonidis S, Sardelli C. Compliance and viewpoint of glaucoma patients in Greece. Eye (Lond) 2000;14(Pt 5):752–756. - PubMed
    1. Yeaw J, Benner JS, Walt JG, Sian S, Smith DB. Comparing adherence and persistence across 6 chronic medication classes. J Manag Care Pharm. 2009;15(9):728–740. - PMC - PubMed
    1. Friedman DS, Quigley HA, Gelb L, et al. Using pharmacy claims data to study adherence to glaucoma medications: Methodology and findings of the Glaucoma Adherence and Persistency Study (GAPS) Invest Ophthalmol Vis Sci. 2007;48(11):5052–5057. - PubMed
    1. Schmier JK, Covert DW, Robin AL. First-year treatment patterns among new initiators of topical prostaglandin analogs. Curr Med Res Opin. 2009;25(4):851–858. - PubMed
    1. Schmier JK, Covert DW, Robin AL. First-year treatment costs among new initiators of topical prostaglandin analogs. Clin Ophthalmol. 2009;3:637–644. - PMC - PubMed