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Randomized Controlled Trial
. 2011 Jul;15(5):919-29.
doi: 10.1007/s10461-010-9828-3.

A preliminary randomized controlled trial of a nurse-delivered medication adherence intervention among HIV-positive outpatients initiating antiretroviral therapy in Beijing, China

Jane M Simoni  1 , Wei-Ti Chen, David Huh, Karen I Fredriksen-Goldsen, Cynthia Pearson, Hongxin Zhao, Cheng-Shi Shiu, Xin Wang, Fujie Zhang
Affiliations
Randomized Controlled Trial

A preliminary randomized controlled trial of a nurse-delivered medication adherence intervention among HIV-positive outpatients initiating antiretroviral therapy in Beijing, China

Jane M Simoni et al. AIDS Behav. 2011 Jul.

Abstract

We evaluated a nurse-delivered adherence intervention in a preliminary randomized controlled trial among 70 HIV-positive outpatients initiating antiretroviral therapy (ART) in Beijing, China. In both arms, participants received a 30-min educational session, a pillbox, and a referral to a peer support group. In the enhanced arm, participants could choose an electronic reminder device, three sessions of counseling either alone or with a treatment adherence partner, or both reminder and counseling. Survey assessments and blood draws occurred at baseline, post-intervention (13 weeks), and follow-up (25 weeks). Primary outcomes were 7-day and 30-day adherence assessed by self-report and electronic drug monitoring (EDM), and secondary outcomes were HIV-1 RNA viral load and CD4 count. The intervention was feasible and well received. It led to some improvement in self-reported and EDM-assessed adherence but not the biological outcomes. Providing counseling and facilitating the use of electronic reminders to patients initiating ART merits further investigation as a culturally viable means of promoting adherence in China.

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Figures

Fig. 1
Fig. 1
Flow chart of participants
Fig. 2
Fig. 2
Self-reported 30-day adherence by study arm according to longitudinal model based on observed data at 7, 13, 19, and 25 weeks. Shaded regions are the 95% confidence intervals
See this image and copyright information in PMC

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