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. 2010 Nov 10;132(44):15531-3.
doi: 10.1021/ja107758d.

Facile synthesis of 2-(phenylthio)phenols by copper(I)-catalyzed tandem transformation of C-S coupling/C-H functionalization

Runsheng Xu  1 , Jie-Ping Wan, Hui Mao, Yuanjiang Pan
Affiliations

Facile synthesis of 2-(phenylthio)phenols by copper(I)-catalyzed tandem transformation of C-S coupling/C-H functionalization

Runsheng Xu et al. J Am Chem Soc. .

Erratum in

  • J Am Chem Soc. 2011 Jan 19;133(2):387

Abstract

2-(Phenylthio)phenols were successfully synthesized from simple phenols and aromatic halides by using dimethyl sulfoxide as the oxidant. The transformation was accomplished via tandem copper(I)-catalyzed C-S coupling/C-H functionalization employing the CuI/L [L = (E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one] catalyst system. The mechanism of the reaction was elucidated based on an isotope labeling strategy.

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