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Randomized Controlled Trial
. 2010 Nov-Dec;19(6):481-9.
doi: 10.1111/j.1521-0391.2010.00076.x. Epub 2010 Sep 21.

A placebo-controlled trial of atomoxetine in marijuana-dependent individuals with attention deficit hyperactivity disorder

Aimee L McRae-Clark  1 , Rickey E Carter, Therese K Killeen, Matthew J Carpenter, Kathleen G White, Kathleen T Brady
Affiliations
Randomized Controlled Trial

A placebo-controlled trial of atomoxetine in marijuana-dependent individuals with attention deficit hyperactivity disorder

Aimee L McRae-Clark et al. Am J Addict. 2010 Nov-Dec.

Abstract

This study evaluated the effects of atomoxetine on the symptoms of attention deficit hyperactivity disorder (ADHD) and marijuana use in marijuana-dependent adults. In conjunction with motivational interviewing, participants received either atomoxetine (n = 19) or matching placebo (n = 19) for 12 weeks. Participants randomized to atomoxetine had greater improvement in ADHD on the Clinical Global Impression-Improvement scale than participants treated with placebo. No treatment group differences in self-rated ADHD symptoms, overall Wender-Reimherr Adult Attention Deficit Disorder Scale scores, or marijuana use outcomes were noted. These results suggest that atomoxetine may improve some ADHD symptoms but does not reduce marijuana use in this population.

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Conflict of interest statement

Declaration of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.

Figures

FIGURE 1
FIGURE 1
Progress of patients in the study
See this image and copyright information in PMC

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