Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2010 Oct 19:10:625.
doi: 10.1186/1471-2458-10-625.

Within-trial economic evaluation of diabetes-specific cognitive behaviour therapy in patients with type 2 diabetes and subthreshold depression

Nadja Chernyak  1 , Bernd Kulzer, Norbert Hermanns, Andreas Schmitt, Annika Gahr, Thomas Haak, Johannes Kruse, Christian Ohmann, Marsel Scheer, Guido Giani, Andrea Icks
Affiliations
Randomized Controlled Trial

Within-trial economic evaluation of diabetes-specific cognitive behaviour therapy in patients with type 2 diabetes and subthreshold depression

Nadja Chernyak et al. BMC Public Health. .

Abstract

Background: Despite the high prevalence of subthreshold depression in patients with type 2 diabetes, evidence on cost-effectiveness of different therapy options for these patients is currently lacking.

Methods/design: Within-trial economic evaluation of the diabetes-specific cognitive behaviour therapy for subthreshold depression. Patients with diabetes and subthreshold depression are randomly assigned to either 2 weeks of diabetes-specific cognitive behaviour group therapy (n = 104) or to standard diabetes education programme only (n = 104). Patients are followed for 12 months. During this period data on total health sector costs, patient costs and societal productivity costs are collected in addition to clinical data. Health related quality of life (the SF-36 and the EQ-5D) is measured at baseline, immediately after the intervention, at 6 and at 12 months after the intervention. Quality adjusted life years (QALYs), and cumulative costs will be estimated for each arm of the trial. Cost-effectiveness of the diabetes-specific cognitive behaviour group therapy will be analysed from the perspective of the German statutory health insurance and from the societal perspective. To this end, incremental cost-effectiveness ratio (ICER) in terms of cost per QALY gained will be calculated.

Discussion: Some methodological issues of the described economic evaluation are discussed.

Trial registration: The trial has been registered at the Clinical Trials Register (NCT01009138).

PubMed Disclaimer

References

    1. Löthgren M. Economic evidence in affective disorders: a review. Eur J Health Econ. 2004;5(1):12–19. doi: 10.1007/s10198-005-0283-4. - DOI - PubMed
    1. Luppa M, Heinrich S, Angermeyer MC, König HH, Riedel-Heller SG. Cost-of-illness studies of depression. A systematic review. J Affect Disord. 2007;98:29–43. doi: 10.1016/j.jad.2006.07.017. - DOI - PubMed
    1. Ali S, Stone MA, Peters JL, Davies MJ, Khunti K. The prevalence of co-morbid depression in adults with type 2 diabetes: a systematic review and meta-analysis. Diabet Med. 2006;23:1165–73. doi: 10.1111/j.1464-5491.2006.01943.x. - DOI - PubMed
    1. Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of co-morbid depression in adults with diabetes: a meta-analysis. Diabetes Care. 2001;24:1069–1078. doi: 10.2337/diacare.24.6.1069. - DOI - PubMed
    1. Hermanns N, Kulzer B, Krichbaum M, Kubiak T, Haak T. Affective and anxiety disorders in a German sample of diabetic patients: prevalence, comorbidity and risk factors. Diabet Med. 2005;22:293–300. doi: 10.1111/j.1464-5491.2005.01414.x. - DOI - PubMed

Publication types

Associated data