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Review
. 2011 May 1;43(10):543-56.
doi: 10.1152/physiolgenomics.00157.2010. Epub 2010 Oct 19.

MicroRNAs in skin and wound healing

Jaideep Banerjee  1 , Yuk Cheung Chan, Chandan K Sen
Affiliations
Review

MicroRNAs in skin and wound healing

Jaideep Banerjee et al. Physiol Genomics. .

Abstract

MicroRNAs (miRNAs) are small endogenous RNA molecules ∼22 nt in length. miRNAs are capable of posttranscriptional gene regulation by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation or suppression of translation. miRNAs have recently been shown to play pivotal roles in skin development and are linked to various skin pathologies, cancer, and wound healing. This review focuses on the role of miRNAs in cutaneous biology, the various methods of miRNA modulation, and the therapeutic opportunities in treatment of skin diseases and wound healing.

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Figures

Fig. 1.
Fig. 1.
MicroRNA (miRNA) biogenesis and posttranscriptional gene silencing mechanisms. pri-miRNA, primary miRNA; pre-miRNA, premature miRNA; RISC, miRNA-induced silencing complex.
Fig. 2.
Fig. 2.
Web-based bioinformatics resources used in miRNA research: PicTar (http://pictar.mdc-berlin.de/), microRNA.org (http://www.microrna.org/), TargetScan (http://www.targetscan.org/), miRGator (http://genome.ewha.ac.kr/miRGator/), StarmiR (http://sfold.wadsworth.org/starmir.pl), EMBL (http://www.russell.embl.de/miRNAs), miRGen targets (http://diana.pcbi.upenn.edu/cgi-bin/miRGen/v3/Targets.cgi), miRBase targets (http://www.mirbase.org/), EIMMo (http://www.mirz.unibas.ch/ElMMo2/), DIANA microT (http://diana.pcbi.upenn.edu/cgi-bin/micro_t.cgi), miRNAMap (http://mirnamap.mbc.nctu.edu/tw/index.php), mirEval (http://tagc.univ-mrs.fr/mireval/), Transterm (http://guinevere.otago.ac.nz/Transterm.html), miR2Disease (http://www.miR2Disease.org), TransmiR (http://202.38.126.151/hmdd/mirna/tf/), miRBase sequence (http://www.mirbase.org/), CoGemiR (http://cogemir.tigem.it/), TarBase (http://diana.cslab.ece.ntua.gr/tarbase/), miRecords (http://mirecords.biolead.org/).
Fig. 3.
Fig. 3.
miRNA-203 acts as a switch between keratinocyte proliferation and differentiation in adult epidermis and thus contributes to skin morphogenesis. TPA, 12-O-tetradecanoylphorbol-13-acetate: PKC, protein kinase C; AP-1, activator protein-1.
Fig. 4.
Fig. 4.
Role of miRNA-210 in the impairment of healing in chronic ischemic wounds. HIF, hypoxia-inducible factor.
Fig. 5.
Fig. 5.
Approaches for miRNA modulation and examples of application. UTR, untranslated region.
Fig. 6.
Fig. 6.
Chemical modifications of oligonucleotides for in vivo delivery. OMe, 2′-O-methyl group.
See this image and copyright information in PMC

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