Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 May;33(5):661-7.
doi: 10.1002/hed.21513. Epub 2010 Oct 19.

Outcomes after definitive treatment for cutaneous angiosarcoma of the face and scalp

B Ashleigh Guadagnolo  1 , Gunar K Zagars, Dejka Araujo, Vinod Ravi, Thomas D Shellenberger, Erich M Sturgis
Affiliations

Outcomes after definitive treatment for cutaneous angiosarcoma of the face and scalp

B Ashleigh Guadagnolo et al. Head Neck. 2011 May.

Abstract

Background: The aim of the present analysis was to retrospectively evaluate outcomes in patients with cutaneous angiosarcoma of the face/scalp treated curatively with surgery, radiation therapy (RT), or a combination of surgery and RT.

Methods: In all, 70 patients with nonmetastatic angiosarcoma underwent surgery, RT, or combined-modality therapy. Of these, 20 patients (29%) were treated with surgery alone, 27 patients (39%) with RT alone, and 23 patients (33%) with combined-modality therapy; 44 patients received chemotherapy, either neoadjuvantly or adjuvantly or both.

Results: Median follow-up was 2.1 years. The overall survival (OS) rate was 43% at 5 years, and disease-specific survival (DSS) was 46% at 5 years. Tumor size > 5 cm and satellitosis were prognostic for inferior OS and DSS. Combined-modality therapy (vs surgery alone or RT alone) was associated with improved OS, DSS, and local control.

Conclusions: Primary local therapy with combined-modality therapy was associated with improved local control, OS, and DSS for patients with angiosarcoma of the face/scalp.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Overall survival, disease-free survival, and disease-specific survival for the entire study population
Figure 2
Figure 2
Disease-specific survival by definitive local therapy
Figure 3
Figure 3
Local control by definitive local therapy
See this image and copyright information in PMC

References

    1. Weiss SW, Goldblum JR. Enzinger and Weiss's Soft Tissue Tumors. Mosby Elsevier; Philadelphia: 2008. Malignant Vascular Tumors. pp. 703–732.
    1. Maddox JC, Evans HL. Angiosarcoma of skin and soft tissue: a study of forty-four cases. Cancer. 1981;48(8):1907–21. - PubMed
    1. Pawlik TM, Paulino AF, McGinn CJ, et al. Cutaneous angiosarcoma of the scalp: a multidisciplinary approach. Cancer. 2003;98(8):1716–26. - PubMed
    1. Buschmann A, Lehnhardt M, Toman N, Preiler P, Salakdeh MS, Muehlberger T. Surgical treatment of angiosarcoma of the scalp: less is more. Ann Plast Surg. 2008;61(4):399–403. - PubMed
    1. Holden CA, Spittle MF, Jones EW. Angiosarcoma of the face and scalp, prognosis and treatment. Cancer. 1987;59(5):1046–57. - PubMed

MeSH terms

Substances