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Review
. 2010 Nov;32(8):579-84.
doi: 10.1097/MPH.0b013e3181edb464.

Treatment of Gorham-Stout disease with zoledronic acid and interferon-α: a case report and literature review

Dawn K Kuriyama  1 , Sean C McElligott, Darryl W Glaser, Karen S Thompson
Affiliations
Review

Treatment of Gorham-Stout disease with zoledronic acid and interferon-α: a case report and literature review

Dawn K Kuriyama et al. J Pediatr Hematol Oncol. 2010 Nov.

Abstract

Gorham-Stout disease is a rare disease characterized by osteolysis, angiomatosis, and soft-tissue swelling. It is a diagnosis of exclusion and has an unknown etiology. Chylothorax is a common complication of the disease that is associated with a high mortality rate. There is no standard of treatment. We report a case of a 16-year-old female with Gorham-Stout disease and recurrent pleural effusions who was successfully treated with concurrent zoledronic acid and peg-interferon α-2b.

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