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Review

Prospects for ensuring acceptance of ES cell-derived tissues

Kathy O Lui  1 , Paul J Fairchild  1 , Herman Waldmann  1
In: StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008.
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Review

Prospects for ensuring acceptance of ES cell-derived tissues

Kathy O Lui et al.
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Excerpt

ES cell-derived tissues exhibit a degree of immune privilege and can be naturally accepted across weak histocompatibility mismatches without any added immunosuppression. This is, in part, due to the lack of donor dendritic cells (DC) which would directly stimulate host T cell responses. In addition to this, there can be recruitment and/or induction of Treg which suppress immune attack against the tissue. This might explain why ES cell-derived tissues are so amenable to tolerance induction protocols, such as co-receptor blockade with monoclonal antibodies, when compared to skin grafts. Co-receptor blockade also appears to enhance the protective effect of regulatory T-cells

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