Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Nov;10(11):775-83.
doi: 10.1038/nrc2943. Epub 2010 Oct 22.

Acute promyelocytic leukaemia: novel insights into the mechanisms of cure

Hugues de Thé  1 , Zhu Chen
Affiliations
Review

Acute promyelocytic leukaemia: novel insights into the mechanisms of cure

Hugues de Thé et al. Nat Rev Cancer. 2010 Nov.

Abstract

The fusion oncogene, promyelocytic leukaemia (PML)-retinoic acid receptor-α (RARA), initiates acute promyelocytic leukaemia (APL) through both a block to differentiation and increased self-renewal of leukaemic progenitor cells. The current standard of care is retinoic acid (RA) and chemotherapy, but arsenic trioxide also cures many patients with APL, and an RA plus arsenic trioxide combination cures most patients. This Review discusses the recent evidence that reveals surprising new insights into how RA and arsenic trioxide cure this leukaemia, by targeting PML-RARα for degradation. Drug-triggered oncoprotein degradation may be a strategy that is applicable to many cancers.

PubMed Disclaimer

References

    1. J Natl Cancer Inst. 1982 Apr;68(4):589-96 - PubMed
    1. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4725-30 - PubMed
    1. Oncogene. 2001 Oct 29;20(49):7257-65 - PubMed
    1. Science. 1990 Sep 28;249(4976):1577-80 - PubMed
    1. Blood. 2010 Sep 30;116(13):2324-31 - PubMed

Publication types

MeSH terms

LinkOut - more resources