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. 2011 Jan;25(1):84-90.
doi: 10.1038/eye.2010.157. Epub 2010 Oct 22.

Cystic macular oedema on spectral-domain optical coherence tomography in choroideremia patients without cystic changes on fundus examination

M A Genead  1 , G A Fishman
Affiliations

Cystic macular oedema on spectral-domain optical coherence tomography in choroideremia patients without cystic changes on fundus examination

M A Genead et al. Eye (Lond). 2011 Jan.

Abstract

Purpose: To determine the prevalence of cystic macular oedema (CME) in patients with choroideremia (CHM) by using spectral-domain optical coherence tomography (SD-OCT).

Methods: A total 16 patients affected with CHM were enrolled in the study. All patients underwent a complete eye examination. SD-OCT was performed using an OPKO spectral-domain OCT/SLO instrument.

Results: The average age of the study patients was 44.0 ± 16.0 years (range, 13-63 years). Out of the 16 patients with CHM, 10 patients (62.5%) showed a degree of CME on SD-OCT testing in at least one eye, and 8 patients (50%) showed CME in both eyes.

Conclusions: Because of its notable prevalence, it would seem prudent to screen CHM patients by SD-OCT for the possible presence of CME and to identify those amenable to future treatment strategies for their macular oedema.

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Figures

Figure 1
Figure 1
Fundus photographs of right eyes in a 13-year-old (a), 44-year-old (b), and 63-year-old (c) choroideremia affected males that show areas of choroidal and RPE atrophy at an earlier stage (a), and more extensive atrophy of the choroid and RPE noted at later stages of the disease (b and c).
Figure 2
Figure 2
Horizontal SD-OCT scans of the left eyes (a and b) and both eyes (c) of three affected males with choroideremia (ages, 62-, 44-, and 63-year-old, respectively), which show evidence of cystic macular oedema in the fovea and parafoveal regions (arrows). Black arrow head (c) shows a rosette-like retinal structure, whereas the white arrow head (b) shows retinal nerve fibre layer thickening temporal to optic nerve (ON). Patient (a) shows evidence of an epiretinal retinal membrane (between the two white lines).
Figure 3
Figure 3
Confocal scanning ophthalmoscopic images (a and c) and retinal thickness measured in early treatment diabetic retinopathy study-like zones (b and d) of the left eyes in two affected males with choroideremia (ages, 62- and 63-year-old, respectively), which show characteristic fundus changes and the presence of central foveal and parafoveal retinal thickening.
See this image and copyright information in PMC

References

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