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. 2011 Jun;22(6):1809-19.
doi: 10.1007/s00198-010-1415-y. Epub 2010 Oct 22.

Parental smoking during pregnancy and offspring bone mass at age 10 years: findings from a prospective birth cohort

C Macdonald-Wallis  1 , J H Tobias, G Davey Smith, D A Lawlor
Affiliations

Parental smoking during pregnancy and offspring bone mass at age 10 years: findings from a prospective birth cohort

C Macdonald-Wallis et al. Osteoporos Int. 2011 Jun.

Abstract

We investigated an intrauterine influence of maternal smoking during pregnancy on childhood bone mass. Daughters, but not sons, of mothers who smoked had higher bone mass at age 10years. This appears to be due to familial factors related to parental smoking influencing increased offspring adiposity rather than a direct intrauterine effect.

Introduction: Neonatal studies have demonstrated an adverse relationship between maternal smoking in pregnancy and foetal bone mineral accrual. We aimed to investigate an intrauterine influence of maternal smoking during pregnancy on offspring bone mass at mean age 9.9 years.

Methods: We compared associations of maternal and paternal smoking in pregnancy with offspring total body less head (TBLH) and spine bone mineral content (BMC), bone area (BA), bone mineral density (BMD) and area-adjusted BMC (ABMC) in 7,121 children in the Avon Longitudinal Study of Parents and Children.

Results: Maternal smoking in any trimester was associated with increased TBLH BMC, BA and BMD in girls (mean difference [95% CI] (sex-specific SD scores), 0.13 [0.05-0.22], 0.13 [0.04-0.21], 0.13 [0.04-0.22], respectively) but not boys (0.01 [-0.07-0.09], 0.00 [-0.08-0.08], 0.04 [-0.05-0.12]), and also with spine BMC, BA and BMD in girls (0.13 [0.03-0.23], 0.12 [0.03-0.22], 0.10 [0.00-0.21]) but not boys (0.03 [-0.06-0.12], 0.00 [-0.09-0.09], 0.05 [-0.04-0.14]), but not with ABMC. Paternal smoking associations were similar, with no statistical evidence for a difference between maternal and paternal effects. Maternal associations increased on adjustment for offspring birth weight and gestational age, but attenuated to the null after adjustment for current height and weight.

Conclusions: We found little evidence that maternal smoking was related to bone mass in boys. In girls, maternal smoking associations were similar to those of paternal smoking, suggesting that these were attributable to shared familial characteristics, not intrauterine mechanisms.

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References

    1. Cooper C, Cawley M, Bhalla A, Egger P, Ring F, Morton L, Barker D. Childhood growth, physical-activity, and peak bone mass in women. J Bone Miner Res. 1995;10:940–947. doi: 10.1002/jbmr.5650100615. - DOI - PubMed
    1. Hernandez CJ, Beaupré GS, Carter DR. A theoretical analysis of the relative influences of peak BMD, age-related bone loss and menopause on the development of osteoporosis. Osteoporos Int. 2003;14:843–847. doi: 10.1007/s00198-003-1454-8. - DOI - PubMed
    1. Clark EM, Ness AR, Bishop NJ, Tobias JH. Association between bone mass and fractures in children: a prospective cohort study. J Bone Miner Res. 2006;21:1489–1495. doi: 10.1359/jbmr.060601. - DOI - PMC - PubMed
    1. Clark EM, Ness AR, Tobias JH. Bone fragility contributes to the risk of fracture in children, even after moderate and severe trauma. J Bone Miner Res. 2008;23:173–179. doi: 10.1359/jbmr.071010. - DOI - PMC - PubMed
    1. Godfrey K, Walker-Bone K, Robinson S, Taylor P, Shore S, Wheeler T, Cooper C. Neonatal bone mass: influence of parental birthweight, maternal smoking, body composition, and activity during pregnancy. J Bone Miner Res. 2001;16:1694–1703. doi: 10.1359/jbmr.2001.16.9.1694. - DOI - PubMed

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