Long-term follow-up of 44 patients with adenocarcinoma of the nasal cavity and sinuses primarily treated with endoscopic resection followed by radiotherapy

Abstract

Background: Endoscopic resection followed by radiotherapy as primary treatment for adenocarcinoma of the sinuses is emerging as an alternative to open resection.

Methods: A total of 44 patients primarily treated by an endoscopic approach followed by radiotherapy from 1992 to 2004 seen at our ENT-Department were analyzed for outcome and prognostic factors.

Results: Median follow-up was 61 months. Median follow-up of the patients alive at the end of the follow-up period was 100 months. For the 5-year follow-up, the overall survival, disease-specific survival, and recurrence-free survival were 63% (±7% SE), 82% (±6), and 60% (±8%), respectively. The overall survival, disease-specific survival, and recurrence-free survival after 100 months of follow-up were 53% (±8%), 72% (±9%), and 54% (±9%), respectively. Four factors significantly influenced the disease-specific survival.

Conclusion: This study of a homogeneous cohort of patients with sinonasal adenocarcinoma treated by endoscopic resection and radiotherapy confirms that endoscopic resection is a valid alternative to open resection.