[Treatment of overactive bladder in women with vitaprost forte]

Abstract

We treated 40 women aged 49-80 years (mean age 63.6 +/- 1.5 years) with overactive bladder (OB). All the patients used suppositoria vitaprost forte once a day before going to bed for 30 days. Miction was assessed before treatment, on treatment day 15 and 30, 30 days after the treatment course. The patients responded to questionnaires on disturbance and discomfort because of miction disorders and kept diary records on miction 3 days before visit to a doctor. The treatment lowered the number of imperative urges by 46%, episodes of urgent incontinence--by 69%. Dyscomfort due to imperative symptoms reduced 2.1-fold, anxiety--by 70%, effects of bladder symptoms on everyday life--by 48%. Satisfaction with treatment results reached 74%. One month after vitaprost forte treatment the subjective and objective miction improvement continued. After the treatment we observed a 20-40% increase in bladder capacity in different urges. This is explained by reduced detrusor ischemia which plays an important role in OB pathogenesis.