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. 2010 Oct 22:10:100.
doi: 10.1186/1471-2288-10-100.

New directions in childhood obesity research: how a comprehensive biorepository will allow better prediction of outcomes

Matthew A Sabin, Susan L Clemens, Richard Saffery, Zoe McCallum, Michele W Campbell, Wieland Kiess, Nancy A Crimmins, Jessica G Woo, Gary M Leong, George A Werther, Obioha C Ukoumunne, Melissa A Wake

New directions in childhood obesity research: how a comprehensive biorepository will allow better prediction of outcomes

Matthew A Sabin et al. BMC Med Res Methodol. .

Abstract

Background: Childhood obesity is associated with the early development of diseases such as type 2 diabetes and cardiovascular disease. Unfortunately, to date, traditional methods of research have failed to identify effective prevention and treatment strategies, and large numbers of children and adolescents continue to be at high risk of developing weight-related disease.

Aim: To establish a unique 'biorepository' of data and biological samples from overweight and obese children, in order to investigate the complex 'gene × environment' interactions that govern disease risk.

Methods: The 'Childhood Overweight BioRepository of Australia' collects baseline environmental, clinical and anthropometric data, alongside storage of blood samples for genetic, metabolic and hormonal profiles. Opportunities for longitudinal data collection have also been incorporated into the study design. National and international harmonization of data and sample collection will achieve required statistical power.

Results: Ethical approval in the parent site has been obtained and early data indicate a high response rate among eligible participants (71%) with a high level of compliance for comprehensive data collection (range 56% to 97% for individual study components). Multi-site ethical approval is now underway.

Conclusions: In time, it is anticipated that this comprehensive approach to data collection will allow early identification of individuals most susceptible to disease, as well as facilitating refinement of prevention and treatment programs.

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Figures

Figure 1
Figure 1
COBRA Recruitment and Baseline Processes.
See this image and copyright information in PMC

References

    1. Dietz WH. Health consequences of obesity in youth: childhood predictors of adult disease. Pediatrics. 1998;101(3 Pt 2):518–525. - PubMed
    1. Sabin MA, Shield JP. Childhood obesity. Front Horm Res. 2008;36:85–96. full_text. - PubMed
    1. O'Rahilly S. Human genetics illuminates the paths to metabolic disease. Nature. 2009;462(7271):307–314. doi: 10.1038/nature08532. - DOI - PubMed
    1. Walley AJ, Asher JE, Froguel P. The genetic contribution to non-syndromic human obesity. Nat Rev Genet. 2009;10(7):431–442. doi: 10.1038/nrg2594. - DOI - PubMed
    1. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW. et al.A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316(5826):889–894. doi: 10.1126/science.1141634. - DOI - PMC - PubMed

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