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Comparative Study
. 1990 Dec;17(2):83-9.
doi: 10.1007/BF01806288.

Epidermal growth factor receptors and prognosis in primary breast cancer

F Spyratos  1 , J C Delarue, C Andrieu, R Lidereau, M H Champème, K Hacène, M Brunet
Affiliations
Comparative Study

Epidermal growth factor receptors and prognosis in primary breast cancer

F Spyratos et al. Breast Cancer Res Treat. 1990 Dec.

Abstract

A retrospective study was performed on 109 human breast tumors stored in liquid nitrogen in order to assess the prognostic value of epidermal growth factor receptor (EGF-R) (median patient follow-up 5 years). A significant inverse relationship was observed between EGF-R and both estrogen (ER) and progesterone receptors (PR). Univariate analysis showed a trend towards a shorter metastasis-free survival both in the overall population and in node-negative patients with EGF-R positive tumors. Multivariate analysis of the overall population showed that lymph-node involvement and PR status were the only significant variables in predicting metastasis-free survival. However, in patients receiving no adjuvant treatment (hormone therapy or chemotherapy). EGF was the only significant variable in the multivariate Cox analysis. No c-erbB-1 amplification was detected in these tumors.

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