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Review
. 2010 Oct;109(10):688-93.
doi: 10.1016/S0929-6646(10)60112-X.

HTLV-1 and adult T-cell leukemia: insights into viral transformation of cells 30 years after virus discovery

Kuan-Teh Jeang  1
Affiliations
Free article
Review

HTLV-1 and adult T-cell leukemia: insights into viral transformation of cells 30 years after virus discovery

Kuan-Teh Jeang. J Formos Med Assoc. 2010 Oct.
Free article

Abstract

Human T-cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell leukemia, was the first human retrovirus to be isolated. It is now the 30(th) anniversary of the initial discovery of HTLV-1. This review discusses recent insights into the role of the HTLV-1 Tax oncoprotein in cellular proliferation and the abrogation of cellular checkpoints that lead to disease progression.

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