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. 2010 Dec 1;20(23):7097-101.
doi: 10.1016/j.bmcl.2010.09.084. Epub 2010 Sep 19.

Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria

Stephen Hanessian  1 , Kandasamy Pachamuthu, Janek Szychowski, Alexandre Giguère, Eric E Swayze, Michael T Migawa, Boris François, Jiro Kondo, Eric Westhof
Affiliations

Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria

Stephen Hanessian et al. Bioorg Med Chem Lett. .

Abstract

Incorporation of an hydrophobic (phenethylamino)ethyl ether at C2″ of N1-(HABA)-3',4'-dideoxyparomomycin led to a novel analog with an excellent antibacterial profile against a host of resistant bacteria.

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