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Case Reports
. 2011 Feb;35(2):139-44.
doi: 10.1016/j.leukres.2010.09.016.

Very late recurrences of leukemia: why does leukemia awake after many years of dormancy?

Maxim Norkin  1 , Joseph P Uberti, Charles A Schiffer
Affiliations
Case Reports

Very late recurrences of leukemia: why does leukemia awake after many years of dormancy?

Maxim Norkin et al. Leuk Res. 2011 Feb.

Abstract

We report a heterogeneous group of very late recurrences of leukemia occurring more than 10 years after initial treatment including 2 cases of childhood acute lymphoblastic leukemia (ALL) which recurred after more than 20 years of remission, 2 cases of donor cell leukemia which developed more than 10 years after allograft for acute myeloid leukemia (AML) and high risk myelodysplastic syndrome (MDS) and 2 cases of chronic myeloid leukemia (CML) relapsing 13 and 17 years after allograft. Case descriptions are followed by a discussion regarding possible mechanisms leading to leukemia recurrence and a review of the literature.

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