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. 2010 Oct 26;20(20):R888-91.
doi: 10.1016/j.cub.2010.09.035.

Calcium signalling: fishing out molecules of mitochondrial calcium transport

György Hajnóczky  1 , György Csordás
Affiliations

Calcium signalling: fishing out molecules of mitochondrial calcium transport

György Hajnóczky et al. Curr Biol. .

Abstract

Cellular energy metabolism, survival and death are controlled by mitochondrial calcium signals originating in the cytoplasm. Now, RNAi studies link three proteins - MICU1, NCLX and LETM1 - to the previously unknown molecular mechanism of mitochondrial calcium transport.

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Figures

Figure 1
Figure 1. Molecular aspects of mitochondrial Ca2+ transport
The scheme depicts the new molecules (MICU1, LETM1 and NCLX, in orange) mediating Ca2+ influx and efflux across the inner mitochondrial membrane (IMM) at an area of endoplasmic reticulum (ER)–mitochondrial association. The shades of gray represent the [Ca2+]: dark gray, 100–500 mM; white, 100 nM. SR, sarcoplasmic reticulum; SERCA, sarcoplasmic ER Ca2 + ATPase; OMM, outer mitochondrial membrane; VDAC, voltage-dependent anion-selective channel; IP3R, inositol 1,4,5-trisphosphate receptor; RyR, ryanodine receptor.
See this image and copyright information in PMC

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