doi: 10.1101/lm.1927310.
Print 2010 Nov.
The effect of D-cycloserine on immediate vs. delayed extinction of learned fear
Affiliations
- PMID: 20971937
- DOI: 10.1101/lm.1927310
Item in Clipboard
The effect of D-cycloserine on immediate vs. delayed extinction of learned fear
Learn Mem.
.
Abstract
We compared the effect of D-cycloserine (DCS) on immediate (10 min after conditioning) and delayed (24 h after conditioning) extinction of learned fear in rats. DCS facilitated both immediate and delayed extinction when the drug was administered after extinction training. However, DCS did not facilitate immediate extinction when administered prior to extinction training (i.e., when the interval between drug administration and shock was reduced). In addition, administering five, but not two, shocks prior to extinction training disrupted the facilitating effects of DCS on delayed extinction. These results suggest that aversive experiences prior to DCS administration can prevent it from facilitating extinction.
Similar articles
-
Effects of multiple exposures to D-cycloserine on extinction of conditioned fear in rats.Neurobiol Learn Mem. 2005 May;83(3):224-31. doi: 10.1016/j.nlm.2005.01.001. Neurobiol Learn Mem. 2005. PMID: 15820858
-
A randomized controlled trial of the effect of D-cycloserine on extinction and fear conditioning in humans.Behav Res Ther. 2007 Apr;45(4):663-72. doi: 10.1016/j.brat.2006.07.005. Epub 2006 Sep 7. Behav Res Ther. 2007. PMID: 16962066 Clinical Trial.
-
D-cycloserine and the facilitation of extinction of conditioned fear: consequences for reinstatement.Behav Neurosci. 2004 Jun;118(3):505-13. doi: 10.1037/0735-7044.118.3.505. Behav Neurosci. 2004. PMID: 15174928
-
Learning and memory in conditioned fear extinction: effects of D-cycloserine.Acta Psychol (Amst). 2008 Mar;127(3):601-13. doi: 10.1016/j.actpsy.2007.07.001. Epub 2007 Aug 17. Acta Psychol (Amst). 2008. PMID: 17707326 Review.
-
Facilitation of fear extinction by D-cycloserine: theoretical and clinical implications.Learn Mem. 2004 Sep-Oct;11(5):510-6. doi: 10.1101/lm.78204. Learn Mem. 2004. PMID: 15466301 Review.
Cited by
-
D-Cycloserine improves sociability in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders with altered Ras/Raf/ERK1/2 signaling.Brain Res Bull. 2013 Jul;96:62-70. doi: 10.1016/j.brainresbull.2013.05.003. Epub 2013 May 15. Brain Res Bull. 2013. PMID: 23685206 Free PMC article.
-
Behavioral and neurobiological mechanisms of extinction in Pavlovian and instrumental learning.Neurobiol Learn Mem. 2014 Feb;108:52-64. doi: 10.1016/j.nlm.2013.08.012. Epub 2013 Aug 30. Neurobiol Learn Mem. 2014. PMID: 23999219 Free PMC article. Review.
-
Mechanisms to medicines: elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders.Br J Pharmacol. 2014 Oct;171(20):4690-718. doi: 10.1111/bph.12779. Epub 2014 Jul 23. Br J Pharmacol. 2014. PMID: 24835117 Free PMC article. Review.
-
Acute, but not chronic, exposure to d-cycloserine facilitates extinction and modulates spontaneous recovery of a conditioned taste aversion.Physiol Behav. 2012 Jan 18;105(2):417-27. doi: 10.1016/j.physbeh.2011.08.041. Epub 2011 Sep 10. Physiol Behav. 2012. PMID: 21925192 Free PMC article.
-
Medial prefrontal cortex activation facilitates re-extinction of fear in rats.Learn Mem. 2011 Mar 23;18(4):221-5. doi: 10.1101/lm.2070111. Print 2011. Learn Mem. 2011. PMID: 21430044 Free PMC article.