Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Nov;10(11):753-66.
doi: 10.1038/nri2858.

Antigen-presenting cell function in the tolerogenic liver environment

Angus W Thomson  1 , Percy A Knolle
Affiliations
Review

Antigen-presenting cell function in the tolerogenic liver environment

Angus W Thomson et al. Nat Rev Immunol. 2010 Nov.

Abstract

The demands that are imposed on the liver as a result of its function as a metabolic organ that extracts nutrients and clears gut-derived microbial products from the blood are met by a unique microanatomical and immunological environment. The inherent tolerogenicity of the liver and its role in the regulation of innate and adaptive immunity are mediated by parenchymal and non-parenchymal antigen-presenting cells (APCs), cell-autonomous molecular pathways and locally produced factors. Here, we review the central role of liver APCs in the regulation of hepatic immune function and also consider how recent insights may be applied in strategies to target liver tolerance for disease therapy.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Immunol. 2003 Mar 1;170(5):2323-30 - PubMed
    1. Trends Immunol. 2005 Dec;26(12):632-6 - PubMed
    1. Nat Med. 2007 Apr;13(4):419-22 - PubMed
    1. Nature. 1969 Aug 2;223(5205):472-6 - PubMed
    1. Gastroenterology. 2008 Sep;135(3):980-8 - PubMed

Publication types

LinkOut - more resources