Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Sep;81(9):674-7.

[Expression of survivin, SDF-1 and CXCR4 on tumor cells in ovarian cancer]

[Article in Polish]
Ewa Nowak-Markwitz  1 , Bartosz Puła, Marta Szajnik, Piotr Dziegiel, Aleksandra Piotrowska, Maciej Zabel, Marek Spaczyński
Affiliations
  • PMID: 20973204

[Expression of survivin, SDF-1 and CXCR4 on tumor cells in ovarian cancer]

[Article in Polish]
Ewa Nowak-Markwitz et al. Ginekol Pol. 2010 Sep.

Abstract

Background: epithelial ovarian cancer (EOC) has the highest mortality rate among patients with gynecologic malignancies. Lack of specific and early symptoms and of screening tests causes that most patients are diagnosed in advanced stage of disease. Radical surgery followed by chemotherapy does not bring satisfactory curative effects.

Objectives: the urgent need exists to define the optimum biomarker for ovarian cancer to predict patients' response to curative therapy. Our current study aimed at correlation between the expression of survivin, SDF-1, CXCR-4 on tumor tissue and clinical outcome of patients with ovarian cancer.

Results: We showed that survivin expression correlates with histological grading of the tumor. No correlation was found in terms of SDF-1/ CXCR-4 expression and clinicopathologic data.

Conclusions: further studies covering larger number of patients are needed to determine whether SDF-1 and CXCR-4 might be considered as biomarkers for ovarian cancer.

PubMed Disclaimer

LinkOut - more resources