Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Nov 17;132(45):15899-901.
doi: 10.1021/ja107447w. Epub 2010 Oct 25.

Bivalent ligands of CXCR4 with rigid linkers for elucidation of the dimerization state in cells

Tomohiro Tanaka  1 , Wataru Nomura, Tetsuo Narumi, Akemi Masuda, Hirokazu Tamamura
Affiliations

Bivalent ligands of CXCR4 with rigid linkers for elucidation of the dimerization state in cells

Tomohiro Tanaka et al. J Am Chem Soc. .

Abstract

To date, challenges in the design of bivalent ligands for G protein-coupled receptors (GPCRs) have revealed difficulties stemming from lack of knowledge of the state of oligomerization of the GPCR. The synthetic bivalent ligands with rigid linkers that are presented here can predict the dimer form of CXCR4 and be applied to molecular probes in cancerous cells. This "molecular ruler" approach would be useful in elucidating the details of CXCR4 oligomer formation.

PubMed Disclaimer

Publication types

LinkOut - more resources