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. 2011 Mar;204(3):230.e1-7.
doi: 10.1016/j.ajog.2010.09.018. Epub 2010 Oct 25.

Familial aggregation of hyperemesis gravidarum

Yafeng Zhang  1 , Rita M Cantor, Kimber MacGibbon, Roberto Romero, Thomas M Goodwin, Patrick M Mullin, Marlena S Fejzo
Affiliations

Familial aggregation of hyperemesis gravidarum

Yafeng Zhang et al. Am J Obstet Gynecol. 2011 Mar.

Abstract

Objective: This study was undertaken to determine whether there is familial aggregation of hyperemesis gravidarum (HG), making it a disease amenable to genetic study.

Study design: Cases with severe nausea and vomiting in a singleton pregnancy treated with intravenous hydration and unaffected friend controls completed a survey regarding family history.

Results: Sisters of women with HG have a significantly increased risk of having HG themselves (odds ratio, 17.3; P = .005). Cases have a significantly increased risk of having a mother with severe nausea and vomiting; 33% of cases reported an affected mother compared to 7.7% of controls (P < .0001). Cases reported a similar frequency of affected second-degree maternal and paternal relatives (18% maternal lineage, 23% paternal lineage).

Conclusion: There is familial aggregation of HG. This study provides strong evidence for a genetic component to HG. Identification of the predisposing gene(s) may determine the cause of this poorly understood disease of pregnancy.

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Figures

FIGURE 1
FIGURE 1
FAMILY A shows inheritance passes through maternal and paternal lines and multiple generations. Black circles=HG, Grey circle=More Severe Morning Sickness, No fill=not affected.
See this image and copyright information in PMC

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