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Review
. 2010 Oct 26;122(17):1740-51.
doi: 10.1161/CIRCULATIONAHA.110.942250.

Hold me tight: Role of the heat shock protein family of chaperones in cardiac disease

Monte S Willis  1 , Cam Patterson
Affiliations
Review

Hold me tight: Role of the heat shock protein family of chaperones in cardiac disease

Monte S Willis et al. Circulation. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Disclosures: The authors do not have any potential conflicts of interest relevant to this article to report.

Figures

Figure 1
Figure 1. The regulation of the protein quality control and chaperone systems in the heart that protect against the toxicity of misfolded proteins
A. Both NF-kB and HSF transcription factors regulate the expression of key molecular chaperones in the mitochondria and cytosol, respectively. Stress-activated HSF1 and HSF2 also increase the expression of co-chaperones and ubiquitin expression. B. The upregulation of both chaperones and ubiquitin help maintain protein quality control by either refolding (chaperone) the protein or ubiquitinating misfolded proteins (co-chaperone, e.g. CHIP). This is a dynamic process particularly important during cardiac stress. Adapted from: Kubota 2009 and Wang et al.
See this image and copyright information in PMC

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