Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Oct 4:2010:840768.
doi: 10.4061/2010/840768.

Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major

Danielle Gomes Passos-Silva  1 , Matheus Andrade Rajão, Pedro Henrique Nascimento de Aguiar, João Pedro Vieira-da-Rocha, Carlos Renato Machado, Carolina Furtado
Affiliations

Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major

Danielle Gomes Passos-Silva et al. J Nucleic Acids. .

Abstract

A wide variety of DNA lesions arise due to environmental agents, normal cellular metabolism, or intrinsic weaknesses in the chemical bonds of DNA. Diverse cellular mechanisms have evolved to maintain genome stability, including mechanisms to repair damaged DNA, to avoid the incorporation of modified nucleotides, and to tolerate lesions (translesion synthesis). Studies of the mechanisms related to DNA metabolism in trypanosomatids have been very limited. Together with recent experimental studies, the genome sequencing of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, has revealed interesting features of the DNA repair mechanism in these protozoan parasites, which will be reviewed here.

PubMed Disclaimer

References

    1. Nussbaum K, Honek J, Cadmus CM, Efferth T. Trypanosomatid parasites causing neglected diseases. Current Medicinal Chemistry. 2010;17(15):1594–1617. - PubMed
    1. de Souza W. Structural organization of Trypanosoma cruzi . Memorias do Instituto Oswaldo Cruz. 2009;104(1):89–100. - PubMed
    1. Schnaufer A, Domingo GJ, Stuart K. Natural and induced dyskinetoplastic trypanosomatids: how to live without mitochondrial DNA. International Journal for Parasitology. 2002;32(9):1071–1084. - PubMed
    1. Stoppani AOM, Docampo R, de Boiso JF, Frasch ACC. Effect of inhibitors of electron transport and oxidative phosphorylation on Trypanosoma cruzi respiration and growth. Molecular and Biochemical Parasitology. 1980;2(1):3–21. - PubMed
    1. Dey R, Meneses C, Salotra P, Kamhawi S, Nakhasi HL, Duncan R. Characterization of a Leishmania stage-specific mitochondrial membrane protein that enhances the activity of cytochrome c oxidase and its role in virulence. Molecular Microbiology. 2010;77(2):399–414. - PMC - PubMed

LinkOut - more resources