Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Dec 1;202(11):1749-53.
doi: 10.1086/657146. Epub 2010 Oct 26.

IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection

Maureen P Martin  1 , Ying Qi, James J Goedert, Shehnaz K Hussain, Gregory D Kirk, W Keith Hoots, Susan Buchbinder, Mary Carrington, Chloe L Thio
Affiliations

IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection

Maureen P Martin et al. J Infect Dis. .

Abstract

An IL28B haplotype strongly determines the outcome of natural and interferon-α treated hepatitis C virus (HCV) infection. To assess whether the polymorphism marking the haplotype (rs12979860) also affects other interferon-α responsive chronic viral illnesses, namely hepatitis B virus (HBV) and human immunodeficiency virus (HIV) type 1 infections, we genotyped 226 individuals with HBV persistence, 384 with HBV recovery, and 2548 with or at high risk for HIV infection. The C/C genotype of rs12979860 was not associated with HBV recovery (odds ratio, 0.99), resistance to HIV infection (odds ratio, 0.97), or HIV disease progression (P > .05). This IL28B single-nucleotide polymorphism affects the immune response to HCV but not to HBV or HIV.

PubMed Disclaimer

Conflict of interest statement

Potential conflicts of interest: none reported.

Figures

Table 1.
Table 1.
rs12979860 and Likelihood of Developing Chronic Hepatitis B Virus (HBV) Infection
Table 2.
Table 2.
rs12979860 and Likelihood of Acquiring Human Immunodeficiency Virus (HIV) Infection
Figure 1.
Figure 1.
Kaplan-Meier survival curves combining all ethnic groups demonstrate no difference in the time to various outcomes of human immunodeficiency virus (HIV) infection based on rs12979860 genotypes C/C, C/T, T/T in 1036 HIV seroconverters. HR, hazard ratio.
See this image and copyright information in PMC

References

    1. Marcello T, Grakoui A, Barba-Spaeth G, et al. Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics. Gastroenterology. 2006;131(6):1887–1898. - PubMed
    1. Thomas DL, Thio CL, Martin MP, et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009;461(7265):798–801. - PMC - PubMed
    1. Ge D, Fellay J, Thompson AJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 2009;461(7262):399–401. - PubMed
    1. Lapenta C, Santini SM, Proietti E, et al. Type I interferon is a powerful inhibitor of in vivo HIV-1 infection and preserves human CD4 +T cells from virus-induced depletion in SCID mice transplanted with human cells. Virology. 1999;263(1):78–88. - PubMed
    1. Hou W, Wang X, Ye L, et al. Lambda interferon inhibits human immunodeficiency virus type 1 infection of macrophages. J Virol. 2009;83(8):3834–3842. - PMC - PubMed

Publication types

Grants and funding