Analgesia: Pain control at the periphery

Comment

Katie Kingwell. Nat Rev Neurosci. 2010 Nov.

. 2010 Nov;11(11):732.

doi: 10.1038/nrn2939.

Abstract

A small molecule that increases endocannabinoid signalling at sensory nerve terminals enhances analgesia.

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.
Clapper JR, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, Duranti A, Tontini A, Sanchini S, Sciolino NR, Spradley JM, Hohmann AG, Calignano A, Mor M, Tarzia G, Piomelli D. Clapper JR, et al. Nat Neurosci. 2010 Oct;13(10):1265-70. doi: 10.1038/nn.2632. Epub 2010 Sep 19. Nat Neurosci. 2010. PMID: 20852626 Free PMC article.