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Randomized Controlled Trial
. 2011 Mar 1;95(3):1174-7.
doi: 10.1016/j.fertnstert.2010.09.023. Epub 2010 Oct 27.

A novel method of luteal supplementation with recombinant luteinizing hormone when a gonadotropin-releasing hormone agonist is used instead of human chorionic gonadotropin for ovulation triggering: a randomized prospective proof of concept study

Evangelos G Papanikolaou  1 , Willem Verpoest, Human Fatemi, Basil Tarlatzis, Paul Devroey, Herman Tournaye
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Free article
Randomized Controlled Trial

A novel method of luteal supplementation with recombinant luteinizing hormone when a gonadotropin-releasing hormone agonist is used instead of human chorionic gonadotropin for ovulation triggering: a randomized prospective proof of concept study

Evangelos G Papanikolaou et al. Fertil Steril. .
Free article

Abstract

This pilot study investigates the role of luteal supplementation with recombinant LH in an attempt to reverse the poor reproductive outcome previously noticed after GnRH-agonist triggering of final oocyte maturation for IVF. Similar implantation rates were achieved with the novel recombinant LH luteal supplementation scheme compared with the standard luteal P protocol (25.0% vs. 26.7%, respectively). No cases of ovarian hyperstimulation syndrome (OHSS) were noticed in either group.

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