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. 2011:2011:892807.
doi: 10.1155/2011/892807. Epub 2010 Sep 28.

Antidiabetic Potentiality of the Aqueous-Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin-Induced Diabetic Male Albino Rat: A Correlative and Evidence-Based Approach with Antioxidative and Antihyperlipidemic Activities

Debasis De  1 , Kausik Chatterjee, Kazi Monjur Ali, Tushar Kanti Bera, Debidas Ghosh
Affiliations

Antidiabetic Potentiality of the Aqueous-Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin-Induced Diabetic Male Albino Rat: A Correlative and Evidence-Based Approach with Antioxidative and Antihyperlipidemic Activities

Debasis De et al. Evid Based Complement Alternat Med. 2011.

Abstract

Antidiabetic, antioxidative, and antihyperlipidemic activities of aqueous-methanolic (2 : 3) extract of Swietenia mahagoni (L.) Jacq. (family Meliaceae) seed studied in streptozotocin-induced diabetic rats. Feeding with seed extract (25 mg 0.25 mL distilled water(-1)100 gm b.w.(-1)rat(-1) day(-1)) for 21 days to diabetic rat lowered the blood glucose level as well as the glycogen level in liver. Moreover, activities of antioxidant enzymes like catalase, peroxidase, and levels of the products of free radicals like conjugated diene and thiobarbituric acid reactive substances in liver, kidney, and skeletal muscles were corrected towards the control after this extract treatment in this model. Furthermore, the seed extract corrected the levels of serum urea, uric acid, creatinine, cholesterol, triglyceride, and lipoproteins towards the control level in this experimental diabetic model. The results indicated the potentiality of the extract of S. mahagoni seed for the correction of diabetes and its related complications like oxidative stress and hyperlipidemia. The extract may be a good candidate for developing a safety, tolerable, and promising neutraceutical treatment for the management of diabetes.

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Figures

Figure 1
Figure 1
Correction of glycogen content in hepatic tissue after administration of aqueous-methanolic extract of S. mahagoni seed in STZ-induced diabetic male albino rat. Each bar represents Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two tail “t” test. Bars diagrams with different superscripts (a,b,c) differ from each other significantly, P < .05.
Figure 2
Figure 2
Resettlement in the activities of peroxidase in kidney, liver, and skeletal muscles after administration of aqueous-methanolic extract of S. mahagoni seed in STZ-induced diabetic male albino rat. Bar expressed as Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail “t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.
Figure 3
Figure 3
Effect of aqueous-methanolic extract of S. mahagoni seed on the activities of catalase in kidney, liver, and skeletal muscles in STZ-induced diabetic male albino rat. Bar represents Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail “t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.
Figure 4
Figure 4
Correction in the levels of urea, uric acid, and creatinine in serum after administration of aqueous-methanolic extract of S. mahagoni seed in STZ-induced diabetic male albino rat. Bar represents Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail `` t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.
Figure 5
Figure 5
Correction in the levels of total cholesterol and triglyceride in serum after treatment of aqueous-methanolic extract of S. mahagoni seed in STZ-induced diabetic male albino rat. Bar are expressed as Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail “t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.
Figure 6
Figure 6
Effect of aqueous-methanolic extract of S. mahagoni seed on serum high density lipoprotein cholesterol (HDLc), low density lipoprotein cholesterol (LDLc) and very low density lipoprotein cholesterol (VLDLc) levels in STZ-induced diabetic rat. Bar represents Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail “t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.
Figure 7
Figure 7
Effect of aqueous-methanolic extract of S. mahagoni seed on the levels of conjugated diene (CD) in kidney, liver, and skeletal muscles in STZ-induced diabetic male albino rat. Bar represents Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail “t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.
Figure 8
Figure 8
Correction in the levels of thio-barbituric acid reactive substances (TBARS) in kidney, liver, and skeletal muscles after administration of aqueous-methanolic seed extract of S. mahagoni in STZ-induced diabetic male albino rat. Values expressed as Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail “t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.
Figure 9
Figure 9
Diagrammatic representation of diabetes induction by STZ (a) and the hypothetical ways the correction of diabetes-induced metabolic disorders by aqueous-methanolic extract of S. mahagoni (b).
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