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Review
. 2011 Mar;28(3):511-28.
doi: 10.1039/c0np00001a. Epub 2010 Oct 28.

Structure and synthesis of 2-aminoimidazole alkaloids from Leucetta and Clathrina sponges

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Review

Structure and synthesis of 2-aminoimidazole alkaloids from Leucetta and Clathrina sponges

Panduka B Koswatta et al. Nat Prod Rep. 2011 Mar.

Abstract

Marine sponges belonging to the Calcarea family have been studied for some time and have yielded a wide variety of structurally unique secondary metabolites. In particular, these sponges have produced a large number of bioactive alkaloids containing an imidazole heterocycle, typically substituted with two benzylic fragments at various locations around the azole nucleus and at various oxidation states. This review will describe the isolation, structural determination and synthetic studies towards this growing class of natural products.

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