Preparation, characterization and in vitro testing of poly(lactic-co-glycolic) acid/barium titanate nanoparticle composites for enhanced cellular proliferation

Abstract

The recent advancements in tissue engineering and, more in general, in cell-based applications, has led to an ever increasing interest toward new materials for sustained cell proliferation and differentiation. Here, the preparation and the characterization of scaffolds based on poly(lactic-co-glycolic) acid / barium titanate nanoparticle composites are presented. In vitro testing on H9C2 cell line demonstrates how the presence of the nanoparticles positively affects both the proliferation and the differentiation of this muscle-like cell line. Finally, the possibility to obtain porous scaffold and, therefore, an actual 3D culture system, is introduced.