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Review
. 1990 Dec;2(6):1099-103.
doi: 10.1016/0955-0674(90)90162-8.

Pseudoknots and the control of protein synthesis

D E Draper  1
Affiliations
Review

Pseudoknots and the control of protein synthesis

D E Draper. Curr Opin Cell Biol. 1990 Dec.
No abstract available

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References

    1. Pleij CWA. Pseudoknots: a new motif in the RNA game. Trends Biochem Sci. 1990;15:143–147. Of interest. - PubMed

    2. A good introduction to the subject of pseudoknots, this recent short review provides a summary of pseudoknot types and geometries, and lists the known occurrences of pseudoknots in viral RNAs, mRNAs, and ribozymes.

    1. Tang CK, Draper DE. An unusual mRNA pseudoknot structure is recognized by a protein translational repressor. Cell. 1989;57:531–536. Of outstanding interest. - PubMed

    2. Compensatory base changes are used to demonstrate conclusively that a pseudoknot fold at the translational initiation site of α mRNA is recognized by a protein. This is a more complex example of pseudoknot folding than most others so far described.

    1. Tang CK, Draper DE. Evidence for allosteric coupling between the ribosome and repressor binding sites of a translationally regulated mRNA. Biochemistry. 1990;29:4434–4439. Of interest. - PubMed

    2. This in vivo study extends the in vitro experiments on the α mRNA pseudoknot, and suggests that the pseudoknot mediates an allosteric interaction between a translational repressor and initiating ribosomes.

    1. Portier C, Dondon L, Grunberg-Manago M. Translational autocontrol of the Escherichia coli ribosomal protein S15. J Mol Biol. 1990;211:407–414. Of interest. - PubMed

    2. Genetic studies establish that the S15 gene is translationally regulated and define the mRNA ‘operator’ sequence needed for this regulation.

    1. Philippe C, Portier C, Mougel M, Grunberg-Manago M, Ebel J-P, Ehresmann B, Ehresmann C. Conformation and interaction with the protein. Vol. 211. 1990. Target site of Escherichia coli ribosomal protein S15 on its messenger RNA; pp. 415–426. (J Mol Biol). Of interest. - PubMed

    2. Extensive ‘structure mapping’ studies on both the S15 mRNA and several mutants argue for a pseudoknot target site for the S15 repressor; the pseudoknot has some interesting parallels to the regulatory site of α mRNA.

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