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. 1975;41(3):249-56.
doi: 10.1007/BF02565060.

Regulation of citrate synthase activity of Saccharomyces cerevisiae

J S Coleman, J K Bhattacharjee

Regulation of citrate synthase activity of Saccharomyces cerevisiae

J S Coleman et al. Antonie Van Leeuwenhoek. 1975.

Abstract

Citrate synthase activity of Saccharomyces cerevisiae was determined by a radioactive assay procedure and the reaction product, 14C-citric acid, was identified by chromatographic techniques. ATP, d-ATP, GTP and NADH were most inhibitory to the citrate synthase invitro. The activity was inhibited to a lesser extent by ADP, UTP, and NADP whereas, AMP and CTP were much less inhibitory. NADH, like NAD, glutamic acid, glutamine, arginine, ornithine, proline, aspartic acid and alpha-ketoglutarate exhibited no inhibition. These results have been discussed in the light of the role of citrate synthase for the energy metabolism and glutamic acid biosynthesis.

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