Lysosomal accumulation of gallium-67 in Morris hepatoma-7316A and Shionogi mammary carcinoma-115
- PMID: 210077
Item in Clipboard
Lysosomal accumulation of gallium-67 in Morris hepatoma-7316A and Shionogi mammary carcinoma-115
Gan.
1978 Apr.
Abstract
Intracellular localization of gallium-67 was investigated in Morris hepatoma-7316A and Shionogi mammary carcinoma-115 cells by the cell fractionation method 48 hr after an intraperitoneal injection of the nuclide. When lysosomes were purified from both tumors by discontinuous sucrose density gradient centrifugation, they had a strikingly high relative specific activity of the nuclide. From these results it was confirmed that gallium-67 is concentrated most specifically in the lysosomes of both tumor cells, which consist chiefly of phagolysosomes and can engulf only limited amount of foreign materials such as Triton and gallium-67.
Similar articles
-
A comparative study on lysosomal accumulation of gallium-67 and indium-111 in Morris hepatoma 7316A.J Nucl Med. 1977 Aug;18(8):835-9. J Nucl Med. 1977. PMID: 194935
-
A quantitative study of the subcellular localization of 67Ga.Cancer Res. 1976 Mar;36(3):956-63. Cancer Res. 1976. PMID: 175954
-
[Clinical and biochemical studies on the mechanism of gallium-67 citrate accumulation in tumor tissues (author's transl)].Nihon Igaku Hoshasen Gakkai Zasshi. 1976 Sep 25;36(9):826-34. Nihon Igaku Hoshasen Gakkai Zasshi. 1976. PMID: 1069242 Japanese. No abstract available.
-
Regulation of DNA synthesis in isolated Morris hepatoma nuclei.Adv Exp Med Biol. 1977 May 22-24;92:233-71. doi: 10.1007/978-1-4615-8852-8_10. Adv Exp Med Biol. 1977. PMID: 76431 Review. No abstract available.
-
Isolation and properties of gamma-glutamyltranspeptidase from Morris hepatoma 5123D.Neoplasma. 1978;25(3):297-308. Neoplasma. 1978. PMID: 28488 Review.
Cited by
-
Biodistributions of radioactive bipositive metal ions in tumor-bearing animals.Biometals. 1994 Apr;7(2):185-92. doi: 10.1007/BF00140490. Biometals. 1994. PMID: 7511950
-
Elevated uptake of 67Ga and increased heparan sulfate content in liver-damaged rats.Eur J Nucl Med. 1983;8(2):52-9. doi: 10.1007/BF00252556. Eur J Nucl Med. 1983. PMID: 6220904 No abstract available.
-
67Ga accumulation and heparan sulfate metabolism in lysosomes.Eur J Nucl Med. 1984;9(2):51-6. doi: 10.1007/BF00254436. Eur J Nucl Med. 1984. PMID: 6231184
-
Subcellular distribution of 111In and 169Yb in tumor and liver.Eur J Nucl Med. 1981;6(5):221-6. doi: 10.1007/BF00290567. Eur J Nucl Med. 1981. PMID: 7250139