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. 1978 Jun;14(6):527-35.
doi: 10.1007/BF02616095.

The reduced extracellular calcium requirement for proliferation by neoplastic hepatocytes

S H Swierenga, J F Whitfield, H P Morris

The reduced extracellular calcium requirement for proliferation by neoplastic hepatocytes

S H Swierenga et al. In Vitro. 1978 Jun.

Abstract

Cells from neonatal rat livers were unable to maintain DNA-synthetic activity in calcium-deficient medium, but neoplastic hepatocytes from Morris hepatomas 5123 tc and 7795 synthesized DNA and proliferated indefinitely in this calcium-deficient medium. The calcium content of fresh hepatoma tissue from which these cultures were derived was as much as 10 times greater than that of normal liver; but this difference could not account for the insensitivity of neoplastic cells to extracellular calcium because it disappeared during subsequent cultivation in vitro.

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