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. 1990;23(8):701-3.

Indomethacin affects the development of tolerance to ethanol-induced diuresis

G S Morato  1 , A M Rosas, S C Bittencourt, A M Chacon
Affiliations
  • PMID: 2101096

Indomethacin affects the development of tolerance to ethanol-induced diuresis

G S Morato et al. Braz J Med Biol Res. 1990.

Abstract

The present study analyzes the effect of indomethacin on the development of tolerance to the diuretic effect of ethanol. Male Wistar rats were treated with ethanol (2 g kg-1 day-1, ip) over a period of 4 weeks and the effect of ethanol on diuresis was assessed weekly. A significant tolerance to the diuretic effect of ethanol was detected after 3 weeks of treatment. However, rats treated simultaneously with ethanol plus indomethacin (5 mg/kg, ip, on alternate days) showed no tolerance to ethanol even after 4 weeks of treatment. The fact that indomethacin prevented the development of tolerance to the diuretic effect of ethanol but had no influence on diuresis per se suggests that prostaglandins play a significant role in the mechanisms of tolerance to ethanol.

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