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Review
. 1990;32(6):387-9.

Fanconi's anemia: genetic and molecular aspects of the defect

E Moustacchi  1 , C Guillouf, D Fraser, F Rosselli, C Diatloff-Zito, D Papadopoulo
Affiliations
  • PMID: 2101869
Review

Fanconi's anemia: genetic and molecular aspects of the defect

E Moustacchi et al. Nouv Rev Fr Hematol (1978). 1990.

Abstract

Several features of Fanconi's anemia (FA) are reported: relative inefficiency in the processing of DNA cross-links and monoadducts, hypomutability at the two loci analysed, complementation of the cytogenetic defect by cocultivation with mouse cells and homology of the FA group A with the mouse cellular mutant MCS attempts to clone and characterise a DNA fragment which complements the defect. The relation between observed features and predisposition to leukemia are discussed.

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