[The correlation between the serum levels of osteocalcin and 24,25-dihydroxyvitamin D in Paget's disease of bone]

Abstract

The influence of 24,25-dihydroxyvitamin D on different seric levels of osteocalcin in Paget's disease of the bone and in 11 of the control group, other parameters were also determined such as: seric levels of calcium, phosphate, parathormone, osteocalcin, 25-hydroxyvitamin D an 1,25 dihydroxyvitamin D. We observed that patients with Paget's disease showed increased or normal levels of seric osteocalcin, despite the high bone remodelling and significantly low level of 24,25-dihydroxyvitamin D observed in patients with high levels of osteocalcin. At the same time, we noticed a negative lineal correlation between both parameters. We suggest that 24,25-hydroxyvitamin D can be one of the important factors in producing increased or normal levels of osteocalcin in patients with Paget's disease of the bone.